Prospective protocol assessing the safety of autologous blood transfusions following pancreatectomy for pancreatic ductal adenocarcinoma (PDAC)

This is a Phase II study that will compare the effects, good and/or bad, of temozolomide versus temozolomide plus capecitabine on advanced pancreatic neuroendocrine tumors cancer to find out which is more effective. In this study, participants will get either temozolomide alone or temozolomide andcapecitabine. Temozolomide and capecitabine are chemotherapy drugs, which have benefited some patients with pancreatic neuroendocrine tumors yet they have never been compared; both arms are considered investigational.

To figure out the best medical follow up of patients after pancreas transplant.

The specific aims of this project are to create a registry, as well as a blood and a tissue bank for individuals with and at high-risk for pancreatic cancer. The personal data derived from the registry, correlated with biological information derived from the tissue specimens will allow for future investigative studies of pancreatic cancer etiology and tumor biology.