Researcher’s Profile

Fay Kastrinos, MD


Dr. Kastrinos is a clinical gastroenterologist with interests related to the genetics, screening, and primary prevention of gastrointestinal tumors, primarily colorectal and pancreatic cancer. She has expertise in the genetic evaluation of patients at risk for hereditary gastrointestinal cancer syndromes and directs a multi-disciplinary specialty clinic at the Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, for genetic risk assessment and cancer prevention in familial gastrointestinal syndromes. She has expertise in clinical cancer genetics, statistical methodology involving the genetic epidemiology of cancer predisposition syndromes, development of prediction models, and analyses of large databases. Her research focus complements her clinical interests and involves optimizing the identification of patients with inherited cancer syndromes and promoting existing and testing novel cancer screening and prevention strategies. She has led large-scale studies, multiple national and international collaborations in developing tools to improve genetic risk assessment for inherited colorectal and pancreatic cancers and developing guidelines for optimal surveillance strategies for individuals at high risk for these cancers. She serves as site-PI at Columbia University for the (i) Cancer of the Pancreas Screening (CAPS) multicenter consortium (U01); (ii) Circulating Biomarker Consortium for the Early Detection of Pancreatic Cancer (U01); (iii) international prospective clinical trial for the validation of a novel biomarker for the early diagnosis of pancreatic cancer in high-risk individuals with familial pancreatic cancer (Immunovia-PanFAM1).

Kastrinos F, Samadder NJ, Burt RW. Use of Family History and Genetic Testing to Determine Risk of Colorectal Cancer. Gastroenterology. 2020; 158(2):389-403. PMID: 31759928
Yurgelun MB, Kastrinos F. Tumor Testing for Microsatellite Instability to Identify Lynch Syndrome: New Insights Into an Old Diagnostic Strategy.J Clin Oncol. 2019; 37(4):263-265. PMID: 30550362
Hasan A, Moscoso DI, Kastrinos F. The role of genetics in pacreatitis. Gastrointest Endosc Clin N Am. 2018; 28(4):587-603. PMID: 30241646
Kastrinos F, Steyerberg EW, Mercado R, Balmaña J, Holter S, Gallinger S, Siegmund KD, Church JM, Jenkins MA, Lindor NM, Thibodeau SN, Burbidge LA, Wenstrup RJ, Syngal S. (2010) The PREMM 1,2,6 Model Predicts Risk of MLH1, MSH2, and MSH6 Germline Mutations Based on Cancer History.
Gastroenterology. Aug 18. :[Epub ahead of print]