Congenital Heart Disease Genetic Network Study
Congenital heart disease (CHD) is the most common birth defect with an incidence of 1 in 100 live births. Many cytogenetic abnormalities have been associated with CHD. Evidence is accumulating that many developmental defects can result from small genomic alterations invisible at the cytogenetic level, resulting in changes in copy number of contiguous genes. As a site in the National Heart, Lung, and Blood Institute-sponsored Pediatric Cardiac Genomics Consortium (PCGC) we will work to help elucidate the potential genetic causes of congenital heart disease. Our goal is to recruit 2000 fa