Phase I Window of Opportunity Study of Parasympathetic Stimulation with Bethanechol in Localized Pancreatic Adenocarcinoma Prior to Surgery
Are you Eligible? (Inclusion Criteria)
Inclusion Criteria:
- ECOG performance status of 0 or 1
- Histologically or cytologically confirmed diagnosis of resectable pancreatic ductal adenocarcinoma or be willing to undergo a biopsy with confirmed pathology prior to starting therapy
Exclusion Criteria:
- Evidence of bacteriuria on U/A within 7 days of study registration
- Currently using an acetylcholinesterase inhibitor or beta blocker
- Active peptic ulcer disease
- Uncontrolled hyperthyroidism
- Bradycardia resting HR <55 BPM
- Chronic hypotension with resting BP <90mmHg. 6. CAD within 5 years prior to study entry
- Seizure disorder
- Latent or active bronchial asthma
Specialty Area(s)
Pancreas