Inclusion Criteria:

• Adult (ages 18-75)
• Hepatitis C Virus ribonucleic acid (HCV RNA) 1000 IU/mL or greater
• Hepatitis C Virus (HCV) genotype 1
• End stage renal disease on hemodialysis
• Females of child bearing potential must be using an adequate method of contraception throughout the study and must have a negative pregnancy test prior to the start of treatment.

Exclusion Criteria:

• Intolerance to peg-IFN or ribavirin with prior treatment course.
• Prior treatment with protease inhibitor (telaprevir or boceprevir) or experimental protease inhibitor
• Significant cytopenias:
  • Absolute neutrophil count (ANC) < 1000/mm3, OR
  • Hemoglobin (Hgb) <10.5 g/dL, or
  • Platelet count < 50,000/mm3
• Significant laboratory abnormalities
  • Direct bilirubin > 1.5 x upper limit of normal (ULN)
  • Total bilirubin > 1.6 mg/dL unless due to Gilbert's disease
  • Prothrombin time (PT)/Partial thromboplastin time (PTT) > 10% above laboratory reference range
  • Thyroid Stimulating Hormone (TSH) > 1.2 x ULN or < 0.8 x lower limit of normal (LLN)
• Uncontrolled depression or psychiatric disease
• Uncontrolled cardiopulmonary or cardiovascular disease
• Autoimmune diseases except for treated thyroid disease
• Active substance abuse within 6 months of initiation of treatment
• Recent (within 4 weeks) episode of infection requiring systemic antibiotics
• Any medical condition that would be predicted to be exacerbated by therapy or that would limit study participation
• Any medical condition requiring or likely to require chronic systemic administration of corticosteroids or other immunosuppressive medications during the course of this study
• Human immunodeficiency virus (HIV) or Hepatitis B Virus (HBV) co-infection
• Hepatocellular carcinoma (HCC) (Patients with HCC who are listed for liver transplantation may be included.)
• Other significant chronic liver disease diagnosis
• Evidence of decompensated liver disease
• Solid organ transplant recipient (Patients who have a history of renal transplant, and have experienced kidney graft loss, and are not on immunosuppression may be included.)