Randomized controlled trial of Vitamin D Repletion Regimens in Primary Hyperparathyroidism

Primary hyperparathyroidism (PHPT) is a condition characterized by overactivity of the parathyroid glands leading to elevated parathyroid hormone and blood calcium levels. Other affected organs include the skeleton (calcium loss leads to a "weakening" of the skeleton), and the kidneys (high blood calcium can lead to kidney stones). Many patients with mild PHPT also have low levels of vitamin D. Both PHPT and Vitamin D Deficiency weaken the skeleton. Recent medical guidelines recommend treating patients with PHPT and low Vitamin D levels with Vitamin D. Treatment with Vitamin D is particularly important in PHPT patients undergoing surgery to prevent postsurgical complications, such as a low blood calcium. This study is designed to determine how vitamin D should be replaced in patients with PHPT and low vitamin D. If you are interested in finding out more information, please contact our Study Coordinator.