Lloyd Ratner, MD, Director, Renal and Pancreatic Transplant Program, provides an easy-to-understand overview of pancreatic transplantation for prospective patients. He discusses how pancreas transplantation can restore glycemic control and reverse secondary complications of kidney disease in patients with type 1 diabetes and kidney failure, patients with brittle diabetes, those with hypoglycemic unawareness, and certain patients with type 2 diabetes.